WordReference Random House Learner's Dictionary of American English © 2025
ˈsick•le ˌcell aˈne•mi•a,  n. [uncountable]
  1. Pathologya hereditary blood disease in which an accumulation of oxygen-deficient blood cells results in anemia.

WordReference Random House Unabridged Dictionary of American English © 2025
sickle cell′ anemia, [Pathol.]
    a chronic hereditary blood disease, occurring primarily among Africans or persons of African descent, in which abnormal hemoglobin causes red blood cells to become sickle-shaped and nonfunctional, characterized by enlarged spleen, chronic anemia, lethargy, weakness, joint pain, and blood clot formation. Also called sick•le•mi•a  (sik′ə lēmē ə, sik lē-).USA pronunciation 
    • 1925–30

'sickle cell anemia' also found in these entries (note: many are not synonyms or translations):

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